Cloud Computing: Protein Sequence Predictions

Cloud computing is a new technology that allows users to access a variety of computing infrastructures on request. It gives users easy access to a large pool of relatively high apps and other infrastructure components. Cloud computing has become increasingly important in biology, geology, and other scientific analysis.

Protein sequence prediction is the biggest analogy of a study area that uses cloud-based applications for processing and storage.

Protein structures are formed by condensing amino acids, which create peptide bonds. A protein's main structure is its sequence of amino acids. The dihedral angles of the peptide bonds determine the secondary structure, while the folding of protein chains in space determines the tertiary structure. Quaternary structure formation occurs when folded polypeptide molecules bind to complex functional proteins.

Protein Structure Prediction Tools

Protein structure prediction can be done using a variety of techniques and technologies. Critical Assessment of Protein Structure Prediction (CASP) is a well-known technology for automated web servers. Research results are stored in clouds like the Continuous Automated Model Evaluation (CAMEO) server. These servers can be accessible by anyone at any time and location, depending on their needs. Phobius, LOMETS, FoldX, Prime, SignalP, Predict Protein, HHpred, BBSP, EVfold, Phre, Biskit, and ESyired3D are some of the technologies or services used in protein structure prediction. New structures are anticipated using these technologies, and the findings are stored on cloud-based databases.

Types of Protein Structure

There are four types of protein structure

Primary Protein Structure:

● Proteins' basic structure is the unique sequencing of amino acids that make up their structures.
● The precise arrangement of proteins is essential since it dictates the protein's overall fold and, as a result, its functionality.
● Proteins are comprised of a diverse amount of polypeptide chains linked together. The amino acids in these sequences are organized in a specific sequence unique to each protein. Any alteration in the protein's structure impacts the complete protein.

Secondary Protein Structure:

● Proteins are made up of more than just polypeptide chains.
● The interaction between the carboxyl groups and amine of the peptide linkage causes these polypeptide chains to fold.
● The structure indicates the likely shape of a lengthy polypeptide chain.
● They can be found in two main kinds of structures: helix and pleated sheet forms.

Tertiary Protein Structure:

● This structure is formed by the additional folding of the protein's secondary structure.
● This structure is stabilized by Van Der Waals forces, electrostatic forces, H-bonds, and disulfide connections.
● The total folding of the polypeptide chains is represented by the tertiary structure of proteins, which is the additional folding of the secondary structure.
● Globular and fibrous molecule morphologies are two of the most common.

Quaternary Protein Structure:

The quaternary structure is formed by the spatial configuration of numerous tertiary structures. Some proteins are made up of sub-units, which are made up of two or many polypeptide chains. Quaternary structure refers to the spatial configuration of these components in relation to one another.

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